Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans
نویسندگان
چکیده
Absorption, metabolism, and excretion (AME) of licogliflozin, a sodium-glucose co-transporters (SGLTs) 1 2 inhibitor, were studied in male rats, dogs, healthy volunteers reported.Oral absorption licogliflozin was rapid (tmax < h) with estimated at 87%, 100% 77% dogs humans, respectively.Excretion licogliflozin-related radioactivity nearly complete following oral administration total recovery ranging from 73% 92.5% to rats. Dose-related excreted both urine faeces urinary playing slightly more important role humans (∼56%) than animal species (∼19–41%).Elimination predominantly via metabolism the majority dose (∼54–74%) as metabolites across species.The principal biotransformation pathways involved direct glucuronidation oxidation all species. In M17 M27 major pathway observed, accounting for ∼38% excreta while oxidative also contributed >29% excreta. Oxidative predominant
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ژورنال
عنوان ژورنال: Xenobiotica
سال: 2021
ISSN: ['1366-5928', '0049-8254']
DOI: https://doi.org/10.1080/00498254.2020.1867331